Electrochemically controlled reconstitution of immobilized ferritins for bioelectronic applications
نویسندگان
چکیده
Site-specific reconstituted nanoparticles were fabricated via electrochemicallycontrolled biomineralization through the immobilization of biomolecules. The work reported herein includes the immobilization of ferritin with various surface modifications, the electrochemical biomineralization of ferritins with different inorganic cores, and the electrocatalytic reduction of oxygen on the reconstituted Pt-cored ferritins. Protein immobilization on the substrate is achieved by anchoring ferritins with dithiobis-Nsuccinimidyl propionate (DTSP). A reconstitution process of site-specific electrochemical biomineralization with a protein cage loads ferritins with different core materials. The ferritin acts as a nano-scale template, a biocompatible cage, and a separator between the nanoparticles. This first demonstration of electrochemically controlled site-specific https://ntrs.nasa.gov/search.jsp?R=20080006495 2017-09-14T00:48:00+00:00Z
منابع مشابه
Biologically Derived Nanoparticle Arrays via an Electrochemical Reconstitution of Ferritin and Their Applications
ABSRACT Nanoparticle arrays biologically derived from an electrochemicallycontrolled site-specific biomineralization were fabricated on a gold substrate through the immobilization process of biomolecules. The work reported herein includes the immobilization of ferritin with various surface modifications, the electrochemical biomineralization of ferritins with different inorganic cores, the fabr...
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